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The theory is straightforward: slower absorption means a gentler onset of the medication effects, reducing the sharp spike that can trigger bloating and nausea in sensitive individuals
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Despite the debated role of GIP signaling in the cardiovascular system, the emergence of GLP-1R/GIPR dual agonists, such as tirzepatide, has resulted in greater improvements in T2DM and weight management than GLP-1RA alone (Lyons & Beaudry 2023)
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